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The goal of our laboratory is to understand how proteins and |
enzyme function at the molecular level and then to translate this knowledge to specifically inhibit the function of these macromolecules in disease. L'enjeu de notre laboratoire est de comprendre le fonctionnement des protéines et des enzymes au niveau moléculaire et d'appliquer ces informations afin d'inhiber spécifiquement la fonction de ces macromolécules dans des maladies.
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Research complement: 6 graduate students (5 PhD level), 1 research technician, 1 senior research associate (contractual); summer students are welcomepositions: please inquire Teaching: Enzymology & Structural Biology Coordination: Professional Masters program 2005-2020 Committees: NSERC GSC 32 2005-2008; Microgravity Discipline Working Group 2008-2010; Head - Professional Masters program 2005-2020; Departmental Research funding: NSERC/CRSNG; CIHR/IRSC; CSA/ASC; Univalor; Ministère de Développement économique, de l'Innovation et de l'Exportation (Québec) |
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1 de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M. (2011) Glycolytic and Non-glycolytic Functions of Myco-bacterium tuberculosis Fructose-1,6-bis-phosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli. J Biol Chem. 286(46): 40219-31Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure. 2021 Mar 4;29(3):261-274. e6. doi: 10.1016/j.str.2020.09.001. Epub 2020 Sep 22.
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