BCM 6200 - Macromolecular Structure

Useful Web links
Protein crystallography




  1. Nuclear Magnetic Resonance Spectroscopy
  2. NMR Relaxation
  3. NMR Indirect Spin-Spin Coupling
  4. NMR Parameters new 02/11/2015
  5. Magnetization Transfer
  6. NMR Pulse Sequences I
  7. NMR Pulse Sequences II
  8. NMR Spectroscopy Studies of Nucleic Acids
  9. NMR Sequential Assignment Strategies
  10. NMR Structure Calculations
  11. NMR Chemical Exchange new 16/11/2015
  12. Structure-based Drug Design

Modelling to be replaced in 2018 with CryoEM Structure Determination

Seminar topics The seminars will be held on Friday December 3rd, 2015 in D-560 at 11H30-15H00 . A Powerpoint or acetate presentation would be appreciated. Your presentation should last no more than 15 minutes leaving time for 5 minutes of questions. Please focus your presentation on the technique used in the article that you have chosen - whenever possible be ready to justify the use of this technique, why it was used and its advantages in the context of its application. Please consult the evaluation profile for which presentation has been assigned to you from the list of seminar topics.
Term paper - 2012 new 13/12/2012

This year instead of an oral presentation, each student will choose from a list of topics and submit a term paper summarizing the technical concepts in their chosen reference. The due date is January 11th, 2013 and it must be submitted electronically.

A recommended format of the term paper should include a title page, an abstract, an introduction to place the importance of the technique in relation to its field, a description of the method, a summary of the results obtained by the method, and importantly your analysis of the method of why it was used and its advantages in the context of its application, and any pertinent references to support your contentions. The acceptable length of the term paper is 10 pages maximum including any figures and tables but excluding the cover page and references. The term paper should use a 12 pt font and have a 2 cm margin all around.

Please append the PDF file of your chosen article to your term paper. Please contact me if you cannot access a PDF copy of your chosen article.
Additional information

  1. Crystallography 101
  2. Crystallographic facts
  3. Protein Crystallography on the Web

Reference Books :

  1. Principles of Protein Crystallography by J. Drenth, Springer-Verlag Inc., New York
  2. Practical Protein Crystallography by D. McRee, Academic Press Inc., San Diego

Pour joindre Jurgen : Téléphone : +1(514)343-2389 Courriel : Jurgen.Sygusch@UMontreal.CA

Coordonnées complètes - Patents