The goal of our laboratory is to understand how proteins and enzymes function at the molecular level and then to translate this knowledge to specifically inhibit the function of these macromolecules in disease.
L'enjeu de notre laboratoire est de comprendre le fonctionnement des protéines et des enzymes au niveau moléculaire et d'appliquer ces informations afin d'inhiber spécifiquement la fonction de ces macromolécules dans des maladies.
Research complement: 6 graduate students (5 PhD level), 1 research technician, 1 senior research associate (contractual); summer students are welcome
Teaching: Enzymology & Structural Biology
Coordination: Professional Masters program
Committees: NSERC GSC 32 2005-2008; Microgravity Discipline Working Group 2008-2010; Head - Professional Masters program; Departmental
Research funding: NSERC/CRSNG; CIHR/IRSC; CSA/ASC; Univalor; Ministère de Développement économique, de l'Innovation et de l'Exportation (Québec)
1 de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M. (2011) Glycolytic and Non-glycolytic Functions of Myco-bacterium tuberculosis Fructose-1,6-bis-phosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli. J Biol Chem. 286(46): 40219-31.
2 Gabin CMB, Arthus-Cartier G, Hannaert V, Thérisod H, Sygusch J*. Thérisod M*. (2011) Mannitol based inhibitors of fructose 1,6-bisphosphate Schiff-base forming aldolase from Trypanosoma brucei. ACS Med. Chem. Lett., 2 (11), 804–808. *Corresponding co-author
3 Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J*, Brisson N. (2012) A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 40(1):258-69 *Corresponding co-author