The Structural Biology Platform at the Université de Montréal offers access to several state-of-the-art scientific instruments intended to answer structural biological questions for the scientific community.
It is comprised of three high field nuclear magnetic resonance (NMR) spectrometers (500 MHz, 600 MHz with cryo-probe and 700 MHz) controlled with recent NEO consoles from Bruker. A small angle X-rays scattering (SAXS) instrument, with high-throughput robotics is also available. The SAXS can be coupled to a liquid chromatography system for SEC-SAXS applications.
Other instruments for biophysical investigations of bio-molecules complement the platform: a size-exclusion chromatography system coupled to a multi-angle light scattering detector (SEC-MALS), an isothermal titration calorimetry (ITC) instrument as well as several liquid handling robots for rapid bio-molecular crystal preparation and screening. Users have also access to a bio-informatics room with several Linux computers for data analysis.
A dedicated qualified personnel is always available and will teach and support users on the instruments in order to maximize the quality of the data acquired at the Platform. Research consultation and turn-key services are also available upon request.
Research services offered
High-field biomolecular nuclear magnetic resonance (NMR)
Size-exclusion chromatography coupled to small-angle X-ray scattering (SEC-SAXS)
Size-exclusion chromatography coupled to multi-angle light scattering (SEC-MALS)
Isothermal titration calorimetry (ITC)
Bioinformatics and Linux cluster for data processing
Fluorescence and UV/VIS spectrophotometry
Complete personnel training and technical support during data acquisition