Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure 28, 1–14 December 1, 2020

Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J*, Rakus D. Targeting moonlighting function of aldolase induces apoptosis in cancer cells. Cell Death Dis. 2019 Sep 26;10(10):712. * Corresponding co-author  

Labiuk SL, Sygusch J*, Grochulski P. Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan. Acta Crystallogr F Struct Biol Commun. 2019 Jun 1;75(Pt 6):405-411. * Corresponding co-author

Arya T, Oudouhou F, Casu B, Bessette B, Sygusch J, Baron C. Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system. Sci Rep. 2019 Apr 24;9(1):6474. doi: 10.1038/s41598-019-42876-6.

Heron P, Abellán-Flos M, Salmon L, Sygusch J. Bisphosphonate inhibitors of mammalian glycolytic aldolase. J Med Chem. 2018 Dec 13;61(23):10558-10572. doi: 10.1021/acs. jmedchem.8b01000. Epub 2018 Dec 3.

Li W, Yazidi A, Pandya AN, Hegde P, Tong W, Calado Nogueira de Moura V, North EJ, Sygusch J, Jackson M. MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections. Front Microbiol. 2018 Jul 10; 9:1547. doi: 10.3389/fmicb.2018.01547. eCollection 2018.

Jacques B, Coinçon M, Sygusch J. Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. J Biol Chem. 2018 May 18;293(20):7737-7753.

Heron P, Sygusch J. Isomer Activation Controls Stereospecificity of Class I FBP Aldolases. J Biol Chem. 2017 Dec 1;292(48):19849-19860.

Oudouhou F, Casu B, Dopgwa Puemi AS, Sygusch J, Baron C. Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43. Biochemistry. 2017 May 2;56(17):2261-2270.

Wahba H, Stevenson M, Mansour A, Sygusch J, Wilcox D, Omichinski J. Structural and biochemical characterization of organotin and organolead compounds binding to the organomercurial lyase MerB provide new insights into its mechanism of carbon-metal bond cleavage. J Am Chem Soc. 2017 Jan 18;139(2):910-921.

Casu B, Smart J, Hancock MA, Smith M, Sygusch J, Baron C. Structural analysis and inhibition of TraE from the pKM101 type IV secretion system. J Biol Chem. 2016 Nov 4;291(45):23817-23829.

Briot J, D’Avanzo N, Sygusch J, Parent, L. Three-dimensional architecture of the L-type calcium channel: Structural insights into the CaV 2 1 auxiliary protein. Biochem Mol Biol Journal, 2016 2(3), 16.

Belardinelli JM#, Yazidi A#, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J*, Jackson M*. Structure-function profile of MmpL3, the essential mycolic acid transporter from Mycobacterium tuberculosis. ACS Infectious Diseases 2016 Oct 14; 2(10):702-713. Epub 2016 Sep 1 * Corresponding co-author   # Equal contributions

Wahba HM, Lecoq L, Stevenson M, Mansour A, Cappadocia L, Lafrance-Vanasse J, Wilkinson KJ, Sygusch J, Wilcox DE, Omichinski JG. Structural and Biochemical Characterization of a Copper-Binding Mutant of the Organomercurial Lyase MerB: Insight into the Key Role of the Active Site Aspartic Acid in Hg-Carbon Bond Cleavage and Metal Binding Specificity. Biochemistry. 2016 Feb 23;55(7):1070-81.

Tanner JE, Coinçon M, Leblond V, Hu J, Fang JM, Sygusch J, Alfieri C. Peptides Designed To Spatially Depict the Epstein-Barr Virus Major Virion Glycoprotein gp350 Neutralization Epitope Elicit Antibodies That Block Virus-Neutralizing Antibody 72A1 Interaction with the Native gp350 Molecule. J Virol. 2015 May 1;89(9):4932-41.

Cappadocia L, Parent JS, Sygusch J*, Brisson N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11): 1207-11. Epub 2013 Oct 26. *Corresponding co-author

Smith MA, Coinçon M, Paschos A, Jolicoeur B, Lavallée P, Sygusch J, Baron C. (2012) Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors. Chem Biol. Aug 24;19(8):1041-8.

Coincon M, Wang W, Sygusch J*, Seah SY. (2012) Crystal structure of reaction intermediates in pyruvate Class II aldolase:  Substrate Cleavage, Enolate Stabilization and Substrate Specificity. J Biol Chem. 287(43):36208-21. Epub 2012 Aug 20. *Corresponding co-author

Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J*, Brisson N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Res. 2012 40(1):258-69. *Corresponding co-author