The goal of our laboratory is to understand how proteins and enzyme function at the molecular level and then to translate this knowledge to specifically inhibit the function of these macromolecules in disease.
L'enjeu de notre laboratoire est de comprendre le fonctionnement des protéines et des enzymes au niveau moléculaire et d'appliquer ces informations afin d'inhiber spécifiquement la fonction de ces macromolécules dans des maladies.
Research positions: no longer accepting students or postdocs - retired
Teaching: Enzymology & Structural Biology
Coordination: Professional Masters program 2005-2020
Committees: NSERC GSC 32 2005-2008; Microgravity Discipline Working Group 2008-2010; Head - Professional Masters program 2005-2020;
Research funding: NSERC/CRSNG; CIHR/IRSC; CSA/ASC; Univalor; Ministère de Développement économique, de l'Innovation et de l'Exportation (Québec)
1 Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J. A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa. Structure. 2021 Mar 4;29(3):261-274. e6. doi: 10.1016/j.str.2020.09.001. Epub 2020 Sep 22.
2 Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J*, Rakus D. Targeting moonlighting function of aldolase induces apoptosis in cancer cells. Cell Death Dis. 2019 Sep 26;10(10):712. doi: 10.1038/s41419-019-1968-4. * Corresponding co-author
3 Heron P, Abellán-Flos M, Salmon L, Sygusch J. Bisphosphonate inhibitors of mammalian glycolytic aldolase. J Med Chem. 2018 Dec 13; 61(23):10558-10572. doi: 10.1021/acs. jmedchem.8b01000. Epub 2018 Dec 3.